Product Details
Appearance:light yellow powder ,insoluble in water
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- Molecular Formula:C20H20O4
- Molecular Weight:324.376
- Appearance/Colour:light yellow powder ,insoluble in water
- Vapor Pressure:2.26E-11mmHg at 25°C
- Melting Point:154-155oC
- Refractive Index:1.622
- Boiling Point:518.555 °C at 760 mmHg
- PKA:9.66±0.40(Predicted)
- Flash Point:267.413 °C
- PSA：58.92000
- Density:1.257 g/cm3
- LogP:4.00070
Glabridin(Cas 59870-68-7) Usage
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Biochem/physiol Actions |
Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. Glabridin has been reported to posses varies biological activities including strong antioxidant activity, antioxidant against LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity and antinephritic and radical scavenging activities. Also it appears to inhibit serotonin re-uptake, melanogenesis, inflammation and cytochrome P450 3A4, 2B6, and 2C9. |
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Definition |
ChEBI: A member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. |
InChI:InChI=1/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
59870-68-7 Relevant articles
Method for synthesizing glabridin
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Paragraph 0031; 0044-0045, (2021/11/14)
The invention relates to a method for sy...
Method for synthesizing optically pure glabridin
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, (2021/11/19)
The invention relates to a method for sy...
Method for asymmetrically synthesizing glabridin with optical purity
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, (2020/07/15)
The invention discloses a method for asy...
A synthesis method of glabridin (by machine translation)
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Paragraph 0024; 0043; 0044, (2019/02/04)
The invention discloses a glabridin synt...
59870-68-7 Process route
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2',4'-dimethylglabridin
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- 59870-68-7
(±)-glabridin
| Conditions | Yield |
|---|---|
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2',4'-dimethylglabridin; With boron tribromide; In dichloromethane; at 0 ℃; for 1.5h; Inert atmosphere;
With methanol; In dichloromethane; for 0.5h; Inert atmosphere;
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100% |
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With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 2h;
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84% |
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With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;
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79% |
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2',4'-di(methoxymethyl)glabridin
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- 59870-68-7
(±)-glabridin
| Conditions | Yield |
|---|---|
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With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 5h;
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59870-68-7 Upstream products
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59870-68-7 Downstream products
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59870-70-1
(R)-3-(2,4-dimethoxyphenyl)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromene
